One of the defining aspects of Leslie Mann's career is her close collaboration with Judd Apatow, whom she married in 1997. This personal and professional partnership has resulted in a string of successful films that have left an indelible mark on the comedy genre. Notable among these collaborations is "The 40-Year-Old Virgin" (2005), where Mann's comedic timing and on-screen chemistry with co-star Paul Rudd contributed to the film's success. The Apatow-directed "Knocked Up" (2007) further solidified Mann's status as a comedic force, showcasing her ability to infuse humor into relatable characters and situations.